The CD53 and CEACAM-1 genes are genetic targets for early B cell factor
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چکیده
منابع مشابه
Cell Cycle Genes Are the Evolutionarily Conserved Targets of the E2F4 Transcription Factor
Maintaining quiescent cells in G0 phase is achieved in part through the multiprotein subunit complex known as DREAM, and in human cell lines the transcription factor E2F4 directs this complex to its cell cycle targets. We found that E2F4 binds a highly overlapping set of human genes among three diverse primary tissues and an asynchronous cell line, which suggests that tissue-specific binding pa...
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Previous studies have suggested that the early-B-cell-specific mb-1(Igalpha) promoter is regulated by EBF and Pax-5. Here, we used in vivo footprinting assays to detect occupation of binding sites in endogenous mb-1 promoters at various stages of B-cell differentiation. In addition to EBF and Pax-5 binding sites, we detected occupancy of a consensus binding site for E2A proteins (E box) in pre-...
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Epstein-Barr virus (EBV) is a ubiquitous B-cell trophic herpesvirus associated with a variety of histologically diverse B-cell lymphomas, each associated with specific viral-latency gene expression programs. Initial infection drives resting B-cells to differentiate via an atypical germinal centre reaction into memory B-cells, where the virus resides in a latent state. The mechanisms that underp...
متن کاملInduction of Early B Cell Factor ( EBF ) and Multiple B Lineage Genes by the Basic Helix - Loop - Helix Transcription Factor
The transcription factors encoded by the E2A and early B cell factor ( EBF ) genes are required for the proper development of B lymphocytes. However, the absence of B lineage cells in E2A and EBF -deficient mice has made it difficult to determine the function or relationship between these proteins. We report the identification of a novel model system in which the role of E2A and EBF in the regu...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2007
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200636642